Safety of Intracochlear Dexamethasone injection through Round Window Membrane in Guinea Pigs

Abstract

Background: Delivering drugs to the cochlea is challenging due to its complex anatomical structure, almost entirely encased in bone. Intratympanic steroid injections are commonly used for inner ear conditions like Meniere’s disease and sudden sensory-neural hearing loss, but they have limitations, including rapid clearance via the Eustachian tube and the need for patients to remain in a supine position post-injection. Intracochlear drug delivery bypasses these limitations, offering potential for more effective treatment.