Synthesis and Evaluation of N-{[5-(Substituted)-1,3,4-Thiadiazole-2-yl] Carbamothioyl} Derivatives as Anti-Inflammatory Agents: A Microwave-Assisted Green Chemistry Approach

Abstract

This study explores the synthesis and anti-inflammatory evaluation of novel N-{[5-(substituted)-1,3,4-thiadiazole-2-yl] carbamothioyl} derivatives using a microwave-assisted green chemistry approach. The synthesized compounds were characterized through FT-IR, NMR, and mass spectrometry. Their anti-inflammatory activity was assessed using the carrageenan-induced paw edema model in rats, revealing significant efficacy in several derivatives. This approach not only reduced reaction times and energy consumption but also demonstrated the potential of these compounds as therapeutic agents.