Collagen-1 Suppression and Fibrosis Prevention by Garcinia Mangostana L. Rind Extract: A Study on NF-κB and TGF-β1 Pathway Inhibition

Abstract

Background: Liver fibrosis is a progressive disease characterized by excessive deposition of extracellular matrix components, such as collagen-1, resulting in tissue scarring and impaired liver function. Activation of the NF-κB and TGF-β1 pathways plays a central role in fibrogenesis. Garcinia mangostana L. rind extract (GMREE) has demonstrated potential anti-fibrotic and anti-inflammatory effects in previous studies. This research investigates the ability of GMREE to suppress collagen-1 production and prevent liver fibrosis by inhibiting the NF-κB and TGF-β1 pathways in an isoniazid-induced fibrosis model in Wistar rats.