In vitro antioxidant and neuroprotective activity of green tea and papaya leaf formulation mediated silver nanoparticles

Abstract

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by oxidative stress, amyloid-beta (Aβ) aggregation, and cholinergic dysfunction. Plant-mediated synthesis of silver nanoparticles (AgNPs) offers a biocompatible approach to target these pathological features. This study investigates the antioxidant, acetylcholinesterase (AChE) inhibitory, and amyloid (Aβ1–42) aggregation inhibitory properties of AgNPs synthesized using green tea and papaya leaf extracts, with a focus on their potential neuroprotective effects.