Anticancer activity of dark chocolate mediated zinc oxide nanoparticles in HT-29 colon cancer cell lines – An in vitro study

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Published: Nov 12, 2024
Keywords:
Anti-cancer, dark chocolate, zinc oxide, nanoparticles, colon cancer

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Khushi Jain D
Department of Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamilnadu, India.
Nitheesh S
Department of Orthopaedics, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Thandalam, Chennai, Tamil Nadu, India.
Parameswari Royapuram Parthasarathy
Centre for Global Health, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Thandalam, Chennai, Tamil Nadu, India.
Geetha R V
Department of Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamilnadu, India.

Abstract

Background: Colorectal cancer is a prevalent malignancy characterized by the transformation of normal cells in the colon or rectum into cancerous cells. Dark chocolate-mediated zinc oxide nanoparticles (DC-ZnO NPs) have emerged as a promising therapeutic approach due to their combined antioxidant and cytotoxic properties. This study investigates the anti-cancer activity of DC-ZnO NPs on HT-29 colon cancer cells, focusing on apoptosis induction, cytotoxicity, and morphological alterations.

Article Details

Issue
Vol. 27 No. 1s (2024)
Section
Articles
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