Evaluation of Oxidative Stress Markers in Chronic Periodontitis: A Comparative Study of Salivary and Serum Levels of 8-OHdG

Abstract

Introduction: Chronic periodontitis is an inflammatory disease characterized by the destruction of the periodontal ligament and alveolar bone. Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) and antioxidants, plays a significant role in its pathogenesis. 8-hydroxydeoxyguanosine (8-OHdG) is a widely recognized marker for oxidative DNA damage. This study aims to compare the levels of 8-OHdG in saliva and serum of chronic periodontitis patients and healthy controls to assess oxidative stress and explore the potential of salivary 8-OHdG as a non-invasive biomarker.