Analysis of Salivary Biomarkers in Periodontal Disease: Correlation of 8-OHdG with Clinical Parameters

Abstract

Background: Periodontal disease is characterized by inflammation and destruction of the tissues supporting the teeth, influenced by microbial infections, host immune response, and oxidative stress. 8-Hydroxydeoxyguanosine (8-OHdG) is a biomarker of oxidative DNA damage. This study investigates the correlation between salivary 8-OHdG levels and clinical parameters of periodontal disease, providing insights into oxidative stress's role in periodontal pathology.