Assessment and Comparison of 8-Hydroxy-2-Deoxyguanosine (8-OHdG) Levels in Saliva and Serum among Healthy Subjects, Periodontitis, and Oral Submucous Fibrosis (OSMF) Patients

Abstract

Introduction: Oxidative stress plays a critical role in the pathogenesis of oral diseases such as periodontitis and oral submucous fibrosis (OSMF). 8-Hydroxy-2-deoxyguanosine (8-OHdG) is a marker of oxidative DNA damage. This study aims to compare 8-OHdG levels in saliva and serum among healthy individuals, periodontitis patients, and OSMF patients to elucidate the extent of oxidative damage in these conditions.